Makinoda S, Tsuruta H, Iwaki M, Negishi H, Hanatani K, Tanaka T, Fujimoto S
Department of Obstetrics and Gynecology, Hokkaido University School of Medicine.
Jpn J Antibiot. 1991 Jun;44(6):652-8.
Flomoxef (FMOX), a new oxacephem with low MIC values against not only Gram-negative bacilli (GNB) but also against Gram-positive cocci (GPC), was evaluated for its transfer into fetus, amniotic fluid, maternal milk, spinal fluid and urine during the perinatal period following a single intravenous drip infusion at a dose of 1 g for 30 minutes. The results obtained are summarized below. 1. High concentrations of FMOX were demonstrated in maternal serum, umbilical arterial serum and amniotic fluid with Cmax values of 48.0, 10.99 and 10.20 micrograms/ml, respectively. 2. Maternal urinary excretion rate was 65.4% in the first 6 hours after administration. 3. In contrast, maternal milk and spinal fluid levels were lower than 3 and 0.20 micrograms/ml, respectively. These results showed a good placental transfer of FMOX, which is very useful for various perinatal infections. No adverse effects were observed in mothers and neonates during the course of this study.
氟氧头孢（FMOX）是一种新型氧头孢烯类抗生素，对革兰氏阴性杆菌（GNB）和革兰氏阳性球菌（GPC）均具有较低的最低抑菌浓度（MIC）值。在围产期，对1g氟氧头孢进行30分钟单次静脉滴注后，评估其向胎儿、羊水、母乳、脑脊液和尿液中的转移情况。所得结果总结如下：1. 母体血清、脐动脉血清和羊水中均显示出高浓度的氟氧头孢，其Cmax值分别为48.0、10.99和10.20微克/毫升。2. 给药后前6小时母体尿液排泄率为65.4%。3. 相比之下，母乳和脑脊液中的浓度分别低于3微克/毫升和0.20微克/毫升。这些结果表明氟氧头孢具有良好的胎盘转运能力，这对于各种围产期感染非常有用。在本研究过程中，未观察到母亲和新生儿出现不良反应。
