大鼠体内抗氧化剂和抗氧化酶与年龄相关的变化

Age-associated changes in antioxidants and antioxidative enzymes in rats.

作者信息

De A K, Darad R

机构信息

Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.

出版信息

Mech Ageing Dev. 1991 Jun 14;59(1-2):123-8. doi: 10.1016/0047-6374(91)90078-e.

DOI:10.1016/0047-6374(91)90078-e

PMID:1890876

Abstract

The antioxidative defence capacity was assessed in tissues from different groups of rats at 3, 12 and 24 months of age. It was observed that the levels of antioxidants, vitamin E and ascorbic acid decreased in serum without any changes in liver; whereas reduced glutathione showed lower levels in both serum and liver with advancing age. Antioxidative enzymes such as superoxide dismutase and catalase activities did not indicate appreciable changes in hepatic mitochondria, but were observed to point out divergent trends in post-mitochondrial supernatants, superoxide dismutase showed reduced activities and catalase activities enhanced with age.

摘要

在3个月、12个月和24个月大的不同组大鼠的组织中评估抗氧化防御能力。观察到血清中的抗氧化剂、维生素E和抗坏血酸水平下降，而肝脏中没有任何变化；而随着年龄的增长，血清和肝脏中的还原型谷胱甘肽水平均降低。超氧化物歧化酶和过氧化氢酶等抗氧化酶的活性在肝线粒体中没有明显变化，但在线粒体后上清液中观察到不同的趋势，超氧化物歧化酶活性降低，而过氧化氢酶活性随年龄增长而增强。