Malaia L T, Rachinskiĭ I D, Shushliapin O I
Kardiologiia. 1976 Dec;16(12):16-25.
A moderate elevation of the daily excretion of free noradrenaline and adrenalin is observed in chronic circulatory insufficiency, beginning with Stage IIA. The catecholamines metabolism is elevated, as shown by the daily excretion of normethanpherine and methanpherine and of vanillyl-mandelic acid. The activity of renin and angiotensinases was growing along with the progressing cardiac insufficiency. The blood level of angiotensinogen was decreasing, especially in patients with Stage IIB and III of decompensation. The daily excretion of aldosterone was growing along with the development of cardiac insufficiency. The functional state of the glucocorticoid function of the adrenal cortex was of a phased nature in cases of circulatory insufficiency. The study of the functional state of the epiphysis was conducted by way of determining the blood level of melatonine and of its daily excretion. In Stages I and IIA the level of this hormone was clearly elevated, in Stages IIB and III -- decreased as compared with the initial and normal levels. The plasma level of the antidiuretic hormone was distinctly growing, beginning with Stage IIB, reaching its maximal values in Stage III.
从IIA期开始，在慢性循环功能不全患者中可观察到游离去甲肾上腺素和肾上腺素的每日排泄量适度升高。儿茶酚胺代谢增强，去甲麻黄碱、麻黄碱和香草扁桃酸的每日排泄量表明了这一点。肾素和血管紧张素酶的活性随着心脏功能不全的进展而增强。血管紧张素原的血药浓度降低，尤其是在失代偿的IIB期和III期患者中。醛固酮的每日排泄量随着心脏功能不全的发展而增加。在循环功能不全的情况下，肾上腺皮质糖皮质激素功能的功能状态呈阶段性。通过测定褪黑素的血药浓度及其每日排泄量来研究松果体的功能状态。在I期和IIA期，这种激素的水平明显升高，在IIB期和III期，与初始水平和正常水平相比有所下降。从IIB期开始，抗利尿激素的血浆水平明显升高，在III期达到最大值。
