家族性非髓样甲状腺癌
Familial nonmedullary thyroid cancer.
作者信息
Ron E, Kleinerman R A, LiVolsi V A, Fraumeni J F
机构信息
Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, Bethesda, Md.
出版信息
Oncology. 1991;48(4):309-11. doi: 10.1159/000226948.
PMID:1891173
Abstract
A 5-fold excess risk of nonmedullary thyroid cancer among close relatives of affected patients was detected in a population-based case-control study of thyroid cancer in Connecticut. The 2 familial cases with early onset and multiple foci suggest genetic susceptibility, whereas the 2 cases with late onset may be related to a common environmental exposure.
摘要
在康涅狄格州一项基于人群的甲状腺癌病例对照研究中，发现甲状腺癌患者的近亲患非髓样甲状腺癌的风险高出5倍。两例早发且多病灶的家族性病例提示存在遗传易感性，而两例晚发病例可能与共同的环境暴露有关。
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