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[抗激肽剂对实验性心肌炎病程的影响]

[Effect of antikinin agents on the course of experimental myocarditis].

作者信息

Surovikina M S, Odinokova V A, Paleev N R, Gurevich M A, Iankovskaia M O

出版信息

Kardiologiia. 1976 Sep;16(9):84-9.

PMID:189119
Abstract

The therapeutic action of 5 preparations: specific antikinin substances -- anginin and contrical, and nonspecific -- epsilon-aminocapronic acid, aspirin and indometacine, was tested in 71 rabbits with allergic myocarditis. It has been concluded that in the allergic distruction of the myocardium plasma kinins, which are formed and accumulated in large quantities, take part in the pathogenesis of the disease serving as mediators of the tissue distruction, therefore specific antagonists of kinins and inhibitors of the kinin system should be included as pathogenetic agents into the complex of allergic myocarditis treatment.

摘要

在71只患有过敏性心肌炎的兔子身上测试了5种制剂的治疗作用:特异性抗激肽物质——血管舒缓素和抑肽酶,以及非特异性物质——ε-氨基己酸、阿司匹林和吲哚美辛。得出的结论是,在心肌的过敏性破坏中,大量形成并积累的血浆激肽参与了疾病的发病机制,作为组织破坏的介质,因此激肽的特异性拮抗剂和激肽系统的抑制剂应作为病因药物纳入过敏性心肌炎的综合治疗中。

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