Sundell C L, Singer R H
Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655.
Science. 1991 Sep 13;253(5025):1275-7. doi: 10.1126/science.1891715.
Specific messenger RNAs (mRNAs) can be sequestered within distinct cellular locations, but little is known about how this is accomplished. The participation of the three major cellular filaments in the localization of actin mRNA was studied in chicken embryo fibroblasts. Movement of actin mRNA to the cell periphery and maintenance of that regionalization required intact microfilaments (composed of actin) but not microtubules or intermediate filaments. The results presented here suggest that actin-binding proteins may participate in mRNA sorting.
特定的信使核糖核酸（mRNA）能够被隔离在不同的细胞位置，但对于这一过程是如何实现的却知之甚少。在鸡胚成纤维细胞中研究了三种主要细胞细丝在肌动蛋白mRNA定位中的作用。肌动蛋白mRNA向细胞周边的移动以及该区域化的维持需要完整的微丝（由肌动蛋白组成），而不需要微管或中间丝。此处呈现的结果表明，肌动蛋白结合蛋白可能参与mRNA分选。
