Mel'nik V P
Vrach Delo. 1991 Jun(6):89-91.
Side-effects of antitubercular drugs were evaluated in 662 patients with tuberculosis. Simultaneously 406 of them suffered of chronic alcoholism, 94 suffered of heavy drinking and 162 were not alcohol abusers. The frequency of side-effects in patients with tuberculosis was 31.5% and 56.4% in those with concomitant alcoholism. The latter showed more frequently negative responses to streptomycin. The latter showed more frequently negative responses to streptomycin, ethionamide, rifampycin and kanamycin. They developed toxic reactions that were three times more frequent than in those without alcohol abuse and were accompanied by exacerbation of diseases of the liver, stomach, heart, CNS, peripheral nervous system.
对662例结核病患者的抗结核药物副作用进行了评估。其中406例同时患有慢性酒精中毒，94例酗酒，162例无酒精滥用。结核病患者的副作用发生率为31.5%，合并酒精中毒者为56.4%。后者对链霉素的阴性反应更为常见。后者对链霉素、乙硫异烟胺、利福平和卡那霉素的阴性反应更为常见。他们出现的毒性反应比无酒精滥用者频繁三倍，且伴有肝脏、胃部、心脏、中枢神经系统、周围神经系统疾病的加重。
