人嗜T淋巴细胞病毒I型的神经嗜性。体外研究。
HTLV-I neurotropism. In vitro studies.
作者信息
Macchi B, Caronti B, Gremo F, Torelli S, Bonmassar E, Lauro G M
机构信息
Department of Experimental Medicine and Biochemical Science, University of Rome, Italy.
出版信息
Acta Neurol (Napoli). 1991 Apr;13(2):179-83.
The human T cell leukemia lymphoma virus (HTLV-I) has been recently associated to neurological disorders. In order to investigate the interaction between this virus and the central nervous system, cells of neuroectodermic origin have been exposed to HTLV-I through an experimental in vitro model. The results revealed the presence of HTLV-I virus core protein p19 inside glial cells, after a short time exposure to a chronically infected donor cell line. This suggests a possible role of a lymphotropic retrovirus in neurological diseases.
人类T细胞白血病淋巴瘤病毒（HTLV-I）最近被认为与神经系统疾病有关。为了研究这种病毒与中枢神经系统之间的相互作用，通过实验性体外模型将神经外胚层来源的细胞暴露于HTLV-I。结果显示，在短时间暴露于慢性感染的供体细胞系后，神经胶质细胞内存在HTLV-I病毒核心蛋白p19。这表明嗜淋巴细胞逆转录病毒在神经疾病中可能发挥作用。
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