Whartenby Katharine A, Small Donald, Calabresi Peter A
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA.
Expert Opin Investig Drugs. 2008 Nov;17(11):1685-92. doi: 10.1517/13543784.17.11.1685.
Autoimmune diseases encompass a broad range of illnesses with a variety of underlying causes, some of which are known and some of which remain elusive.
The focus of this review will be on describing the development of a new type of therapy that could potentially treat T cell-mediated autoimmune diseases. Unlike traditional therapies, which have primarily focused on suppressing T cells directly, targeting the step of antigen presentation may allow a less toxic therapy in which autoimmunity is lessened without compromising the entire immune system. This review will outline the science behind the development of the therapy, the roles of dendritic cells in generating autoimmune disease, and the function of the FLT3 receptor in this process.
自身免疫性疾病涵盖了一系列病因多样的疾病,其中一些病因已知,一些仍不清楚。
本综述的重点将是描述一种新型疗法的发展,这种疗法有可能治疗T细胞介导的自身免疫性疾病。与主要直接抑制T细胞的传统疗法不同,针对抗原呈递步骤可能会产生一种毒性较小的疗法,在不损害整个免疫系统的情况下减轻自身免疫。本综述将概述该疗法发展背后的科学、树突状细胞在引发自身免疫性疾病中的作用以及FLT3受体在此过程中的功能。