Köhler Hugo Fontan, Neves Rogério Izar, Brechtbühl Eduard Rene, Mattos Granja Nara Valeria, Ikeda Mauro Kazuo, Kowalski Luiz Paulo
Department of Head and Neck Surgery and Otolaryngology, Hospital A C Camargo, São Paulo, Brazil.
Otolaryngol Head Neck Surg. 2008 Oct;139(4):519-24. doi: 10.1016/j.otohns.2008.07.022.
To report a single-institution experience in the treatment of cutaneous head and neck angiosarcoma.
Case series.
Twenty-three patients were evaluated: 12 females and 11 males. The primary site of the lesion was the neck in 9 patients, the scalp in 9, and the face in 5. No patient had been submitted to previous treatment but 10 were submitted to incisional biopsy. The lesions' size ranged from 2.5 to 12 cm (median 4 cm).
All but one patient were submitted to surgical resection as primary treatment. Twenty-two patients received adjuvant treatment: 8 cases of local recurrence and 12 cases of distant metastasis. Two patients presented synchronous local and distant relapses. The 5-year survival rate was 21.7 percent. In our series, the only factor affecting survival was histological grade (odds ratio = 6.7; 95% confidence interval, 1.6-28.9).
Our results for 5-year survival are comparable to those in the literature with a treatment based on complete surgical resection. The only significant prognostic factor was tumor histological grade.
报告单中心治疗皮肤头颈部血管肉瘤的经验。
病例系列。
评估了23例患者，其中女性12例，男性11例。病变的主要部位为颈部9例，头皮9例，面部5例。除1例患者外，均未接受过先前治疗，但10例患者接受了切开活检。病变大小范围为2.5至12厘米（中位数4厘米）。
除1例患者外，所有患者均接受手术切除作为主要治疗方法。22例患者接受了辅助治疗，其中8例局部复发，12例远处转移。2例患者出现同步局部和远处复发。5年生存率为21.7%。在我们的系列研究中，影响生存的唯一因素是组织学分级（比值比=6.7；95%置信区间，1.6 - 28.9）。
我们的5年生存率结果与文献中基于完全手术切除的治疗结果相当。唯一重要的预后因素是肿瘤组织学分级。
