鼻内镜鼻窦手术对鼻咽癌患者放射性鼻窦炎的影响。
Effect of endoscopic sinus surgery on irradiation-induced rhinosinusitis in patients with nasopharyngeal carcinoma.
作者信息
Hu Ko-Hsin, Tan Ching-Ting, Lin Kai-Nan, Cheng Ya-Jian, Huang Hung-Meng
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Department of Health, Keelung Hospital, Taipei, Taiwan.
出版信息
Otolaryngol Head Neck Surg. 2008 Oct;139(4):575-9. doi: 10.1016/j.otohns.2008.07.006.
OBJECTIVES
We evaluated the effect of endoscopic sinus surgery on irradiation-induced rhinosinusitis of the maxillary-sinus mucosa among patients with nasopharyngeal carcinoma (NPC).
DESIGN
Surgical outcomes were evaluated by changes to the ultrastructure of the antral mucosa and nasomucociliary clearance.
METHODS
Twenty-one NPC patients with irradiation-induced chronic sinusitis were enrolled in the study, along with five controls. Specimens were taken from 42 maxillary sinuses during surgery and 1 year after surgery. Saccharin transit time was measured before the initial surgery and 1 year after surgery.
RESULTS
In the postoperative cases, we found a decrease in the number of the submucosal gland openings (P < 0.05), the cilia in the antral mucosa regenerated (P < 0.05), and the saccharin transit time reduced (P < 0.05); the number of goblet cells did not change.
CONCLUSION
Endoscopic sinus surgery is an effective treatment for irradiation-induced rhinosinusitis in NPC patients, improving ventilation and drainage of the paranasal sinuses, and facilitating regeneration of the sinus mucosa.
目的
我们评估了鼻内镜鼻窦手术对鼻咽癌（NPC）患者上颌窦黏膜放射性鼻窦炎的影响。
设计
通过上颌窦黏膜超微结构的变化和鼻黏液纤毛清除功能来评估手术效果。
方法
21例患有放射性慢性鼻窦炎的NPC患者以及5名对照者纳入本研究。在手术期间及术后1年从42个上颌窦采集标本。在初次手术前及术后1年测量糖精转运时间。
结果
术后病例中，我们发现黏膜下腺开口数量减少（P < 0.05），上颌窦黏膜中的纤毛再生（P < 0.05），糖精转运时间缩短（P < 0.05）；杯状细胞数量未改变。
结论
鼻内镜鼻窦手术是治疗NPC患者放射性鼻窦炎的有效方法，可改善鼻窦的通气和引流，并促进鼻窦黏膜再生。
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