土耳其鼻息肉患者中HLA - A、- B、- Cw和 - DRB1等位基因频率的评估。
Evaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposis.
作者信息
Keles Bahar, Cora Tülin, Acar Hasan, Arbag Hamdi, Inan Ziya, Ozturk Kayhan, Ozer Bedri
机构信息
Department of Otolaryngology-Head and Neck Surgery, Selcuk University, Meram, Konya, Turkey.
出版信息
Otolaryngol Head Neck Surg. 2008 Oct;139(4):580-5. doi: 10.1016/j.otohns.2008.07.002.
OBJECTIVE
To evaluate whether there is a relationship between HLA-A, -B, -Cw, and -DRB1 alleles and developing nasal polyposis (NP).
STUDY DESIGN
Data from 66 patients with NP were compared with data from 100 healthy randomly selected controls. Asthma, ASA (acetylsalicylic acid) triad, polyp score, and previous sinonasal surgery were also recorded.
SUBJECTS AND METHODS
Genotyping of the HLA-A, -B, -Cw, and -DRB1 alleles were performed with polymerase chain reaction (PCR) with the sequence-specific primer (SSP) method. Data were analyzed by using a Pearson chi(2) test.
RESULTS
The HLA-B07 and -Cw12 alleles were found to be significantly higher in the NP patients compared with the control group, whereas the HLA-B57 and HLA-Cw04 alleles were significantly lower (P < 0.05). The HLA-A24, HLA-Cw12, and HLA-DRB1*04 alleles were determined to be significantly higher in the NP patients with asthma and ASA triad (P < 0.05).
CONCLUSIONS
Our results show that some of the HLA alleles seem to be associated with the genetic susceptibility to develop NP in the Turkish population.
目的
评估人类白细胞抗原（HLA）-A、-B、-Cw和-DRB1等位基因与鼻息肉（NP）发生之间是否存在关联。
研究设计
将66例NP患者的数据与100例随机选取的健康对照者的数据进行比较。还记录了哮喘、阿司匹林三联征、息肉评分和既往鼻窦手术情况。
研究对象与方法
采用序列特异性引物（SSP）聚合酶链反应（PCR）对HLA-A、-B、-Cw和-DRB1等位基因进行基因分型。数据采用Pearson卡方检验进行分析。
结果
与对照组相比，NP患者中HLA-B07和-Cw12等位基因显著更高，而HLA-B57和HLA-Cw04等位基因显著更低（P<0.05）。在患有哮喘和阿司匹林三联征的NP患者中，HLA-A24、HLA-Cw12和HLA-DRB1*04等位基因显著更高（P<0.05）。
结论
我们的结果表明，在土耳其人群中，某些HLA等位基因似乎与发生NP的遗传易感性相关。
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