2-芳氧基甲基吗啉组胺H(3)拮抗剂。
2-Aryloxymethylmorpholine histamine H(3) antagonists.
作者信息
Letavic Michael A, Keith John M, Ly Kiev S, Bonaventure Pascal, Feinstein Mark A, Lord Brian, Miller Kirsten L, Motley S Timothy, Nepomuceno Diane, Sutton Steven W, Carruthers Nicholas I
机构信息
Johnson & Johnson Pharmaceutical Research & Development L.L.C., San Diego, CA 92121-1126, USA.
出版信息
Bioorg Med Chem Lett. 2008 Nov 1;18(21):5796-9. doi: 10.1016/j.bmcl.2008.09.077. Epub 2008 Sep 24.
PMID:18922693
Abstract
The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H(3) antagonists is described. The new compounds are high affinity histamine H(3) ligands that penetrate the CNS and occupy the histamine H(3) receptor in rat brain.
摘要
描述了一系列新型2-芳氧基甲基吗啉组胺H(3)拮抗剂的合成及其生物活性。这些新化合物是高亲和力的组胺H(3)配体，能够穿透中枢神经系统并占据大鼠脑中的组胺H(3)受体。
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