Liu Yilun, West Stephen C
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Genes Dev. 2008 Oct 15;22(20):2737-42. doi: 10.1101/gad.1732808.
Bloom's syndrome is caused by mutations in the BLM gene. The BLM gene product, BLM helicase, forms a complex with two other proteins, DNA topoisomerase IIIalpha and RMI1. In this issue of Genes & Development, Wang and colleagues (2843-2855) and Meetei and colleagues (2856-2868) report the discovery of a fourth component of this complex called RMI2. RMI2 may be a representative of a new family of OB-fold-containing proteins that are important for complex stabilization and checkpoint response.
布卢姆综合征由BLM基因的突变引起。BLM基因产物BLM解旋酶与另外两种蛋白质DNA拓扑异构酶IIIα和RMI1形成复合物。在本期《基因与发育》中，王及其同事（第2843 - 2855页）以及梅泰及其同事（第2856 - 2868页）报告发现了该复合物的第四个组分，称为RMI2。RMI2可能是一个含OB折叠的新蛋白质家族的代表，该家族对于复合物的稳定和检查点反应很重要。
