Vergoulas G, Ioannidis I, Nikodimopoulou M, Miserlis Gr, Solonaki F, Panou E, Posa L, Fousas J, Papagiannis A, Papanikolaou V, Takoudas D
Organ Transplant Unit, Hippokratio General Hospital, Thessaloniki, Greece.
Hippokratia. 2008 Jul;12(3):176-80.
It has been reported that racial and ethnic (genetic make up), as well as socioeconomic differences may affect the results of kidney transplantation. Socioeconomic factors are quite difficult to differentiate from genetic factors. It is not surprising that a group with poorer access to health care, less private insurance and less income does less well with serious medical problems. The aim of this study was to compare the outcomes of kidney transplantations in Greek (G) and Albanian (A) patients.
Twenty nine transplanted patients of Albanian ancestry were matched with 29 Greek patients retrospectively. Their mean age was 34 (G) and 31 (A) years, there were 21 men and 8 women in each group (G, A) and they received 26 kidneys from living related donors and 3 kidneys from cadaveric donors respectively. Arterial blood pressure (ABP), body weight (BW), serum creatinine, serum total protein and albumin, total cholesterol, HDL-cholesterol and triglycerides, 24 hour proteinuria were measured on 7th, 15th postoperative day, 1st , 3rd , 6th month and 1st year after transplant. BMI was calculated before and 1 year after transplantation and acute rejection episodes were recorded too. Methylprednizolone (MP), cyclosporine (CsA) dose /kg BW were calculated at baseline, 1, 3, 6, 12 months after transplant. Cumulative patient and graft survival at 1 and 5 years were calculated too.
Patient survival at 1 and 5 years was 100% / 93.1% and 100% /93.1% respectively (p: NS). Graft survival at 1 and 5 years was 100% / 93.10% and 93.75% / 86.45% respectively (p: NS). BW (but not BMI) and total cholesterol levels in Greek patients were higher compared to those of Albanian patients during the 1st post transplant year (p: 0.044 and p: 0.021 respectively). MP dose in A patients was higher during the first year (p: 0.05).
Patients and graft survival do not present difference between G and A patients. There is significant difference on cholesterol profile between G and A patients. A larger number of transplants are possibly needed to allow us to draw firm conclusions.
据报道，种族和民族（基因构成）以及社会经济差异可能会影响肾移植的结果。社会经济因素很难与基因因素区分开来。获得医疗保健的机会较少、私人保险较少且收入较低的群体在患有严重医疗问题时表现较差，这并不奇怪。本研究的目的是比较希腊（G）和阿尔巴尼亚（A）患者肾移植的结果。
回顾性地将29例有阿尔巴尼亚血统的移植患者与29例希腊患者进行匹配。他们的平均年龄分别为34岁（G组）和31岁（A组），每组（G组、A组）均有21名男性和8名女性，他们分别接受了26个来自活体亲属供体的肾脏和3个来自尸体供体的肾脏。在术后第7天、第15天、第1个月、第3个月、第6个月和第1年测量动脉血压（ABP）、体重（BW）、血清肌酐、血清总蛋白和白蛋白、总胆固醇、高密度脂蛋白胆固醇和甘油三酯、24小时蛋白尿。在移植前和移植后1年计算体重指数（BMI），并记录急性排斥反应发作情况。在移植后基线、1个月、3个月、6个月、12个月计算甲泼尼龙（MP）、环孢素（CsA）的剂量/千克体重。还计算了1年和5年时患者和移植物的累积生存率。
1年和5年时患者生存率分别为100%/93.1%和100%/93.1%（p：无显著性差异）。1年和5年时移植物生存率分别为100%/93.10%和93.75%/86.45%（p：无显著性差异）。在移植后的第1年，希腊患者的体重（但不包括BMI）和总胆固醇水平高于阿尔巴尼亚患者（分别为p：0.044和p：0.021）。A组患者在第一年的MP剂量较高（p：0.05）。
G组和A组患者的患者及移植物生存率没有差异。G组和A组患者的胆固醇水平存在显著差异。可能需要更多的移植病例才能得出确凿的结论。
