Arciola C R
Int J Artif Organs. 2008 Sep;31(9):749-51. doi: 10.1177/039139880803100901.
The role of biofilm in implant infections and the genetic control of its production are still giving rise to great interest and controversial new results are continuing to emerge from widespread investigations. Bacteria embedded in biofilms are more resistant to most antibiotics. Hypotheses regarding the mechanisms of antibiotic multi-resistance in biofilm are brought to light, including the onset of persister cells during the attachment of bacteria to implant surfaces.This 2008 special issue ''Focus on Implant Infections'', presents new strategies for combating biofilm infections,such as the use of staphylococcal quorum-sensing inhibitors or the ''bioelectric effect'': the phenomenon by which electric current can enhance the activity of some antimicrobial agents against bacteria in biofilms.
生物膜在植入物感染中的作用及其产生的基因控制仍然引起了极大的关注，广泛的研究不断涌现出有争议的新结果。嵌入生物膜中的细菌对大多数抗生素更具抗性。关于生物膜中抗生素多重耐药机制的假说被揭示出来，包括在细菌附着于植入物表面过程中持久细胞的出现。这本2008年的特刊《聚焦植入物感染》介绍了对抗生物膜感染的新策略，例如使用葡萄球菌群体感应抑制剂或“生物电效应”：即电流可增强某些抗菌剂对生物膜中细菌活性的现象。
