Kiran M D, Giacometti A, Cirioni O, Balaban N
Cummings School of Veterinary Medicine, Department of Biomedical Sciences,Tufts University, North Grafton, Massachusetts - USA.
Int J Artif Organs. 2008 Sep;31(9):761-70. doi: 10.1177/039139880803100903.
Staphylococcal spp. are notorious for causing biofilm-related device-associated infections, leading to tens of thousands of deaths per year. In this paper, we review quorum sensing inhibitors as potential therapeutics for even the most persistent infections. The animal models reviewed are subcutaneous graft, central venous catheter (CVC), ureteral stent and wound models, and a wound case study. The therapeutic approaches reviewed are the use of RNAIII inhibiting peptide (RIP) and its non-peptide analog. These have been shown to prevent or treat infections caused by any staphylococcal strain tested, including antibiotic-resistant strains like CA-MRSA USA300.
葡萄球菌属因引起与生物膜相关的器械相关感染而臭名昭著，每年导致数万人死亡。在本文中，我们综述了群体感应抑制剂作为治疗甚至最顽固感染的潜在疗法。所综述的动物模型有皮下移植模型、中心静脉导管（CVC）模型、输尿管支架模型和伤口模型，以及一个伤口病例研究。所综述的治疗方法是使用RNAIII抑制肽（RIP）及其非肽类似物。这些已被证明可预防或治疗所测试的任何葡萄球菌菌株引起的感染，包括像社区获得性耐甲氧西林金黄色葡萄球菌USA300这样的耐抗生素菌株。
