Kim Suhyun, Kim Seok-Hyung, Kim Ho, Chung Ah-Young, Cha Yong I, Kim Cheol-Hee, Huh Tae-Lin, Park Hae-Chul
Graduate School of Medicine, Korea University, Ansan, Gyeonggido, Republic of Korea.
Dev Dyn. 2008 Nov;237(11):3324-31. doi: 10.1002/dvdy.21739.
Oligodendrocytes are the myelinating cells in the central nervous system. The development of oligodendrocytes is mediated by complex signaling networks, including Wnt signaling. Although Wnt signaling has been studied in various aspects of neurogenesis, the distinct roles of various Frizzled receptors that mediate the Wnt signaling in the CNS remain virtually unknown. In order to understand the specific function of Wnt signaling in oligodendrocyte development, we focused on the Frizzled 8a (Fz8a) receptor. Here we show that Fz8a plays a critical role in the specification and maturation of oligodendrocyte progenitor cells (OPCs) in the ventral spinal cord. Loss of Fz8a function perturbed the proliferation and organization of radial glial cells that give rise to OPCs in the ventral precursor region of spinal cord. In addition, we demonstrate that Wnt signaling activation after the specification of OPCs blocks the formation of mature oligodendrocytes and results in the elimination of OPCs.
少突胶质细胞是中枢神经系统中的髓鞘形成细胞。少突胶质细胞的发育由包括Wnt信号在内的复杂信号网络介导。尽管Wnt信号已在神经发生的各个方面进行了研究，但介导中枢神经系统中Wnt信号的各种卷曲受体的不同作用实际上仍不清楚。为了了解Wnt信号在少突胶质细胞发育中的特定功能，我们聚焦于卷曲8a（Fz8a）受体。在此我们表明，Fz8a在脊髓腹侧少突胶质前体细胞（OPC）的特化和成熟中起关键作用。Fz8a功能丧失扰乱了脊髓腹侧前体区域中产生OPC的放射状胶质细胞的增殖和组织。此外，我们证明，OPC特化后Wnt信号激活会阻止成熟少突胶质细胞的形成并导致OPC的消除。
