[Osteopontin (OPN), PDGF-BB (platelet-derived growth factor) and BMP-7 (bone morphogenetic protein) as markers of atherogenesis in children with chronic kidney disease (CKD) treated conservatively--preliminary results].

UNLABELLED

Cardiovascular complications are the main cause of morbidity and mortality among patients with CKD. It is common knowledge that in atherogenesis the disorders of calcium--phosphate metabolism count. The molecules of paramount importance are OPN and BMP-7, inhibiting calcification, and PDGF-BB, facilitating this process.

THE AIM OF THE STUDY

to assess the concentrations of the above mentioned factors and their correlation with other markers of atherogenesis in children with CKD.

MATERIAL AND METHODS

OPN, PDGF-BB and BMP-7 plasma concentrations were assessed by ELISA in 18 patients with CKD (stage: I-IV) and in 12 patients from the control group. Ca-P parameters and the lipid profile were also estimated in both groups.

RESULTS

OPN concentrations were comparable in both groups. PDGF-BB median values were lower (p < 0.05) and BMP-7 concentrations--higher in CKD patients than in the controls (p < 0.005). The PDGF-BB concentrations correlated negatively with OPN (R = -0.75, p < 0.001) and CRP (R = -0.71, p < 0.05) in CKD children. The negative correlation was also observed between OPN concentrations and hematocrit (R = -0.49, p < 0.04) and hemoglobin (R = -0.48, p < 0.04) values. In all patients the levels of Ca, P, alkaline phosphatase and PTH were within the normal range.

CONCLUSIONS

The increase of BMP-7 concentrations and decrease of PDGF-BB values in children with CKD, coexisting with well controlled Ca-P metabolism parameters, may suggest early mobilization of mechanisms protecting against vascular calcification. These changes seem independent of dyslipidemia.