Toledo-Corral Claudia M, Roberts Christian K, Shaibi Gabriel Q, Lane Christianne J, Higgins Paul B, Davis Jaimie N, Weigensberg Marc J, Goran Michael I
Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089-9073, USA.
J Pediatr Endocrinol Metab. 2008 Sep;21(9):855-64. doi: 10.1515/jpem.2008.21.9.855.
The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 +/- 1.7 yr; body mass index: 28.2 +/- 5.4 kg/m2). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, p < 0.001 and r = -0.25, p < 0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, p < 0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, p = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children.
本研究旨在探讨178名超重西班牙裔青少年（11.2±1.7岁；体重指数：28.2±5.4kg/m²）中胰岛素样生长因子-I（IGF-I）、IGF结合蛋白（IGFBPs）与肥胖之间的相互关系。采用免疫放射分析方法测定IGF-I、IGFBP-1和IGFBP-3。通过双能X线吸收法（DEXA）测量总脂肪和瘦组织质量，通过磁共振成像（MRI）测量内脏和皮下脂肪组织。在控制协变量后，IGF-I和IGFBP-3仍与全身脂肪量呈负相关（分别为r = -0.52，p < 0.001和r = -0.25，p < 0.01）。在简单相关性分析中，IGFBP-1与总脂肪量呈负相关（r = -0.55，p < 0.001）；然而，在控制协变量后这种关系消失（r = 0.02，p = 0.85）。与内脏和皮下脂肪组织的相关性分析得出了类似结果。这些结果表明，在西班牙裔儿童中，IGF-I、IGFBP-1和IGFBP-3均与肥胖呈负相关。
