Dolynchuk K N
University of Manitoba, Winnipeg, Canada.
Burns. 1991 Jun;17(3):185-7. doi: 10.1016/0305-4179(91)90100-u.
Plasma fibronectin levels, assayed by rocket immunoelectrophoresis, were measured in adult burn patients with 25-75 per cent total body surface area burns. Significant differences in the level of plasma fibronectin were detected in the one fatally injured patient prior to death (at 48 and 24 h) as a precipitous and persistent drop to 0.07 and 0.09 g/l, respectively. This deficiency coincided with early clinical signs of sepsis, the severity of which was not clinically apparent prior to overwhelming sepsis and incipient shock. This report supports previous suggestions that secondary deficiencies in plasma fibronectin may be predictive of mortality occurring after day 6 postburn. The need for routine assay of plasma fibronectin using rocket immunoelectrophoresis is demonstrated.
采用火箭免疫电泳法检测了成年烧伤患者的血浆纤维连接蛋白水平，这些患者的烧伤面积为体表面积的25%至75%。在一名最终死亡的患者死亡前（48小时和24小时）检测到血浆纤维连接蛋白水平存在显著差异，其分别急剧且持续下降至0.07克/升和0.09克/升。这种缺乏与败血症的早期临床症状同时出现，在严重败血症和早期休克出现之前，其严重程度在临床上并不明显。本报告支持了先前的观点，即血浆纤维连接蛋白的继发性缺乏可能预示烧伤后第6天之后发生的死亡。证明了使用火箭免疫电泳法对血浆纤维连接蛋白进行常规检测的必要性。
