A neuromuscular transmission block produced by a cancer tissue extract derived from a patient with the myasthenic syndrome.
作者信息
Ishikawa K, Engelhardt J K, Fujisawa T, Okamoto T, Katsuki H
出版信息
Neurology. 1977 Feb;27(2):140-3. doi: 10.1212/wnl.27.2.141.
PMID:189256
Abstract
The myasthenic syndrome occasionally is associated with bronchogenic carcinoma. The neuromuscular transmission defect in this syndrome is characterized by a reduction of acetylcholine release from motor nerve endings. This paper reports that an acetone extract of cancer tissue from a patient with the syndrome reduces the acetylcholine release from motor nerve endings and produces a neuromuscular transmission defect in the frog nerve-muscle preparation. This suggests that the pathogenic substance(s) contained in the extract may be produced by certain types of bronchogenic carcinoma and may cause the myasthenic syndrome.
摘要
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引用本文的文献
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Eaton-Lambert syndrome: a clinical and electrophysiological study of a patient treated with 4-aminopyridine.伊顿-兰伯特综合征：一例接受4-氨基吡啶治疗患者的临床与电生理研究。
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