Sanders D B, Kim Y I, Howard J F, Goetsch C A
J Neurol Neurosurg Psychiatry. 1980 Nov;43(11):978-85. doi: 10.1136/jnnp.43.11.978.
In a patient with the Eaton-Lambert syndrome, 4-aminopyridine produced temporary improvement of clinical and electromyographic abnormalities. Application of the drug in vitro to intercostal muscle from the patient produced an increase in the evoked release of neurotransmitter from intramuscular nerves.
在一名伊顿-兰伯特综合征患者中,4-氨基吡啶使临床和肌电图异常得到了暂时改善。将该药物体外应用于患者的肋间肌,可使肌内神经递质的诱发性释放增加。