Synthesis of Arabino glycosyl triazoles as potential inhibitors of mycobacterial cell wall biosynthesis.
作者信息
Wilkinson Brendan L, Long Hilary, Sim Edith, Fairbanks Antony J
机构信息
Department of Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
出版信息
Bioorg Med Chem Lett. 2008 Dec 1;18(23):6265-7. doi: 10.1016/j.bmcl.2008.09.082. Epub 2008 Sep 26.
PMID:18926698
Abstract
A series of arabino glycosyl triazoles with varying hydrophobic groups were synthesised as putative mimics of decaprenolphosphoarabinose (DPA) as potential inhibitors of mycobacterial cell wall biosynthesis. Biological testing against Mycobacterium bovis BCG revealed low to moderate anti-mycobacterial activity, with strong dependence on the identity of the hydrophobic side chain.
摘要
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