Wahlin A, Holm J, Engman K
Department of Medicine, University Hospital, Umeå, Sweden.
Acta Oncol. 1991;30(5):611-5. doi: 10.3109/02841869109092428.
Four patients with Philadelphia chromosome positive CML were treated with 18-42 x 10(6) IU of purified natural leukocyte IFN-alpha per week, after high-dose chemotherapy for blast phase and attainment of 2nd chronic phase. The second blast phase occurred within 3 months in 3 patients, but one patient is still in second chronic phase after 22 months of treatment. Treatment consisted of interferon only during the first year, and interferon in combination with hydroxyurea during the second year. During the second year suppression of the Philadelphia chromosome was seen in one patient, with 20% Philadelphia negative bone marrow metaphases. The toxicity of purified natural leukocyte IFN-alpha was similar to the toxicity of recombinant IFN-alpha. Antibodies to IFN-alpha were not detected in any patient.
4例费城染色体阳性慢性粒细胞白血病患者在急变期接受大剂量化疗并进入第二次慢性期后，每周接受18 - 42×10⁶IU纯化天然白细胞干扰素-α治疗。3例患者在3个月内出现第二次急变期，但1例患者在治疗22个月后仍处于第二次慢性期。第一年仅用干扰素治疗，第二年干扰素与羟基脲联合使用。第二年有1例患者出现费城染色体抑制，20%的骨髓中期细胞费城染色体阴性。纯化天然白细胞干扰素-α的毒性与重组干扰素-α相似。所有患者均未检测到干扰素-α抗体。
