Martins Andrew, Lautens Mark
Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6.
J Org Chem. 2008 Nov 21;73(22):8705-10. doi: 10.1021/jo8020105. Epub 2008 Oct 18.
The synthesis of a variety of polycyclic thiophenes and benzothiophenes is accomplished via a palladium-catalyzed domino ortho-alkylation/direct arylation reaction. An examination of the intramolecular direct arylation of thiophenes suggests that an electrophilic metalation mechanism may be present. This method was further extended to include the synthesis of a (thieno)benzoxepine.
通过钯催化的多米诺邻位烷基化/直接芳基化反应实现了多种多环噻吩和苯并噻吩的合成。对噻吩分子内直接芳基化的研究表明，可能存在亲电金属化机制。该方法进一步扩展到包括（噻吩并）苯并氧杂䓬的合成。
