Liu Qiong, Zhu Yu, Qiu Hong-Xia, Qiu Hai-Rong, Wang Rong, Xu Wei, Li Jian-Yong
Department of Hematology, The First Hospital, Nanjing Medical University, Jiangsu Province People Hospital, Nanjing 210029, Jiangsu Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):993-6.
To investigate the chromosome-8 aberrations in myeloid malignancies with complex chromosome abnormalities (CCAs), 81 cases of myeloid malignancies with CCAs were analysed by conventional chromosome analysis and multiplex fluorescence in situ hybridization. The 81 cases included 25 cases of acute myeloid leukemia (AML), 35 cases of chronic myeloid leukemia (CML) and 21 cases of myelodysplastic syndrome (MDS). The results showed that all chromosomes were involved in CCAs, and the incidence of chromosome-8 abnormality was 35.8% (29 out of 81 cases) in myeloid malignancies with CCAs, which in AML, CML and MDS patients were 56% (14/25), 28.6% (10/35) and 23.81% (5/21), respectively. In CML, the incidences of accelerated phase and blast phase were 20% (1/5) and 33.3% (9/27), respectively. The most common aberrations involving chromosome 8 were unbalanced translocations (19 out of 29 cases, 51.7%). In conclusion, aberrations of chromosome 8 were common in myeloid malignancies with CCAs, and may be related to progression of the disease. The most common aberrations were unbalanced translocations.
为研究伴有复杂染色体异常（CCA）的髓系恶性肿瘤中的8号染色体畸变，采用常规染色体分析和多重荧光原位杂交技术对81例伴有CCA的髓系恶性肿瘤病例进行了分析。这81例病例包括25例急性髓系白血病（AML）、35例慢性髓系白血病（CML）和21例骨髓增生异常综合征（MDS）。结果显示，所有染色体均参与了CCA，伴有CCA的髓系恶性肿瘤中8号染色体异常的发生率为35.8%（81例中的29例），其中AML、CML和MDS患者的发生率分别为56%（14/25）、28.6%（10/35）和23.81%（5/21）。在CML中，加速期和急变期的发生率分别为20%（1/5）和33.3%（9/27）。涉及8号染色体的最常见畸变是不平衡易位（29例中的19例，51.7%）。总之，8号染色体畸变在伴有CCA的髓系恶性肿瘤中很常见，可能与疾病进展有关。最常见的畸变是不平衡易位。
