Qin Lan, Yuan Zhong, DU Xiao-Jun, Ma Xi-Hu
Department of Hematology, Traditional Chinese Medicine Hospital, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Oct;16(5):1219-21.
Traditional treatment of chronic idiopathic thrombocytopenic purpura (CITP) is usually adopted as hormonal therapy. If necessary, it also can be given immunosuppressive therapy. In order to investigate the curative effect of rhIL-11 on patients with ITP, 26 patients were divided into control group and rhIL-11 group, each group with 13 patients. Control group was given traditional hormonal therapy and immunosuppressive therapy, while rhIL-11 group was given rhIL-11 on base of traditional therapy. rhIL-11 25 microg/(kg.d) was injected s.c. for 28 days. The results showed that 23 out of 26 patients obtained obviously curative effect in platelet count, especially in rhIL-11 group, but another 3 patients had no response on therapy. The platelet counts of control and rhIL-11 groups increased from 26.15 x 10(9)/L and 27.84 x 10(9)/L before treatment to 66.62 x 10(9)/L and 105.62 x 10(9)/L after treatment. The platelet count of rhIL-11 group after treatment was remarkably higher than that of the control group (p < 0.05). Platelet count of 8 patients in rhIL-11 group recovered to normal. It is concluded that rhIL-11 combined with traditional hormone-immuno-suppressive therapy is effective to CITP.
慢性特发性血小板减少性紫癜（CITP）的传统治疗通常采用激素疗法。必要时，也可给予免疫抑制治疗。为了研究重组人白细胞介素-11（rhIL-11）对特发性血小板减少性紫癜（ITP）患者的疗效，将26例患者分为对照组和rhIL-11组，每组13例。对照组给予传统激素疗法和免疫抑制治疗，而rhIL-11组在传统疗法基础上加用rhIL-11。rhIL-11 25μg/（kg·d）皮下注射，共28天。结果显示，26例患者中有23例血小板计数获得明显疗效，尤其是rhIL-11组，但另外3例患者治疗无效。对照组和rhIL-11组的血小板计数从治疗前的26.15×10⁹/L和27.84×10⁹/L分别升至治疗后的66.62×10⁹/L和105.62×10⁹/L。rhIL-11组治疗后的血小板计数显著高于对照组（p<0.05）。rhIL-11组有8例患者血小板计数恢复正常。结论：rhIL-11联合传统激素-免疫抑制疗法对CITP有效。
