Brown Pamela J B, Hardy Gail G, Trimble Michael J, Brun Yves V
Department of Biology, Indiana University, Bloomington, IN 47405-3700, USA.
Adv Microb Physiol. 2009;54:1-101. doi: 10.1016/S0065-2911(08)00001-5.
Caulobacter crescentus has become the predominant bacterial model system to study the regulation of cell-cycle progression. Stage-specific processes such as chromosome replication and segregation, and cell division are coordinated with the development of four polar structures: the flagellum, pili, stalk, and holdfast. The production, activation, localization, and proteolysis of specific regulatory proteins at precise times during the cell cycle culminate in the ability of the cell to produce two physiologically distinct daughter cells. We examine the recent advances that have enhanced our understanding of the mechanisms of temporal and spatial regulation that occur during cell-cycle progression.
新月柄杆菌已成为研究细胞周期进程调控的主要细菌模型系统。诸如染色体复制与分离以及细胞分裂等特定阶段的过程，与四种极性结构的发育相互协调：鞭毛、菌毛、柄和固着器。特定调节蛋白在细胞周期的精确时间进行产生、激活、定位和蛋白水解，最终使细胞能够产生两个生理上不同的子细胞。我们研究了最近的进展，这些进展加深了我们对细胞周期进程中发生的时间和空间调控机制的理解。
