Zupanc Mary L, Haut Sheryl
Department of Neurology and Pediatrics, Division of Pediatric Neurology, Pediatric Comprehensive Epilepsy Program, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Int Rev Neurobiol. 2008;83:91-111. doi: 10.1016/S0074-7742(08)00005-6.
Adolescence is a time of many changes. It is a time of growing independence, physical and emotional change, accompanied by social insecurity. Girls tend to enter puberty ahead of their male peers, growing and changing physically. Our culture tells adolescents that they are still immature, but their bodies are saying otherwise. The adolescents are also becoming aware of themselves as individuals, separate from their parents, and are presented with the challenges of independent thinking and action. If, in the midst of all of these changes, an adolescent is given the diagnosis of a chronic disease such as epilepsy, there is an additional burden. Often the adolescent must go through a variety of emotions, including shame, denial, anger, and sadness. Our role as medical providers is to provide some perspective to the illness and help guide our adolescent patient through the tumultuous emotions of grieving and acceptance. We must provide a foundation of assistance and emotional support, as well as medical knowledge. With a firm but compassionate hand, we can help them cope with their disorder. In this chapter, Drs. Haut and Zupanc explore some of the unique considerations in adolescent women with epilepsy. The first part of the chapter deals with the epidemiologic diagnosis of epilepsy in adolescence, the effect of epilepsy on reproductive health, hormonal influences on epilepsy (including catamenial seizures), and the effects of antiepileptic drugs (AEDs) on hormones, contraception, and bone health. In the second part of the chapter, we deal with the very real psychosocial issues and comorbidities of epilepsy, including quality of life, school performance, depression, migraine headaches, social stigma, and lifestyle changes. In the final section, the authors suggest strategies for clinical patient management.
青春期是一个充满诸多变化的时期。这是一个逐渐走向独立、身体和情感发生变化,同时伴有社会不安全感的时期。女孩往往比同龄男孩更早进入青春期,身体不断成长和变化。我们的文化告诉青少年他们仍不成熟,但他们的身体却并非如此。青少年也开始意识到自己是独立于父母的个体,并面临着独立思考和行动的挑战。如果在所有这些变化之中,一名青少年被诊断出患有诸如癫痫这样的慢性疾病,那将是额外的负担。通常,青少年必须经历各种情绪,包括羞耻、否认、愤怒和悲伤。我们作为医疗服务提供者的角色,是为这种疾病提供一些观点,并帮助引导我们的青少年患者度过悲伤和接受的动荡情绪。我们必须提供援助和情感支持的基础,以及医学知识。用坚定而富有同情心的手,我们可以帮助他们应对疾病。在本章中,豪特博士和祖潘茨博士探讨了青少年女性癫痫患者的一些独特考量因素。本章第一部分论述青春期癫痫的流行病学诊断、癫痫对生殖健康的影响、激素对癫痫的影响(包括经期发作)以及抗癫痫药物(AEDs)对激素、避孕和骨骼健康的影响。在本章第二部分,我们讨论癫痫非常现实的心理社会问题和合并症,包括生活质量、学业表现、抑郁、偏头痛、社会污名以及生活方式的改变。在最后一部分,作者提出了临床患者管理的策略。