Gutierrez Mary A, Mushtaq Romila, Stimmel Glen
Department of Pharmacology and Outcomes Sciences, Loma Linda University School of Pharmacy, Loma Linda, California 92350, USA.
Int Rev Neurobiol. 2008;83:157-67. doi: 10.1016/S0074-7742(08)00008-1.
Sexual dysfunction is a frequently encountered comorbid disorder in patients with neurological and psychiatric disorders. Importantly, sexual dysfunction can also occur as a treatment emergent adverse effect of a number of commonly used psychotropic and antiepileptic medications, and can include decreased libido, erectile dysfunction, disordered arousal, delayed orgasm, and anorgasmia. These effects can occur in both men and women, and can be seen across age groups. Understanding the neurobiology of normal sexual response, as well as the pharmacologic mechanisms of these commonly used medications can enable the clinician to predict how medication use may impact different phases of sexual response. Discussion of the current treatment strategies for female sexual dysfunction is also elucidated in this chapter.
性功能障碍是神经和精神疾病患者中常见的共病性疾病。重要的是，性功能障碍也可能作为多种常用精神药物和抗癫痫药物的治疗中出现的不良反应而发生，并且可能包括性欲减退、勃起功能障碍、性唤起障碍、性高潮延迟和性高潮缺失。这些影响在男性和女性中均可发生，且可见于各个年龄组。了解正常性反应的神经生物学以及这些常用药物的药理机制，可使临床医生预测药物使用可能如何影响性反应的不同阶段。本章还阐述了当前女性性功能障碍的治疗策略。
