咪唑并[5,1-f][1,2,4]三嗪-2-胺作为Polo样激酶1的新型抑制剂
Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
作者信息
Cheung M, Kuntz K W, Pobanz M, Salovich J M, Wilson B J, Andrews C W, Shewchuk L M, Epperly A H, Hassler D F, Leesnitzer M A, Smith J L, Smith G K, Lansing T J, Mook R A
机构信息
GlaxoSmithKline, Fire Moore Drive, Research Triangle Park, NC 27709, USA.
出版信息
Bioorg Med Chem Lett. 2008 Dec 1;18(23):6214-7. doi: 10.1016/j.bmcl.2008.09.100. Epub 2008 Oct 2.
PMID:18929484
Abstract
The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.
摘要
报道了作为新型polo样激酶1抑制剂的咪唑并[5,1-f][1,2,4]三嗪-2-胺（咪唑三嗪）的合成及生物活性。
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