Garvey M, DeRubeis R J, Hollon S D, Evans M D, Tuason V B
Department of Psychiatry, University of Iowa College of Medicine, Iowa City.
Biol Psychiatry. 1991 Jul 1;30(1):57-62. doi: 10.1016/0006-3223(91)90070-3.
Forty-five depressed patients were treated with imipramine for 6 weeks. Seven of 7 patients (100%) who had plasma levels of imipramine plus desipramine greater than 500 ng/ml showed a 50% or greater improvement in Hamilton depression scores compared with 23 of 38 patients (60%) with plasma levels less than 500 ng/ml (p less than 0.057).
45名抑郁症患者接受了6周的丙咪嗪治疗。丙咪嗪加去甲丙咪嗪血浆水平大于500 ng/ml的7名患者中有7名（100%）汉密尔顿抑郁评分改善了50%或更多，相比之下，血浆水平低于500 ng/ml的38名患者中有23名（60%）（p<0.057）。
