Horan William P, Kern Robert S, Shokat-Fadai Karina, Sergi Mark J, Wynn Jonathan K, Green Michael F
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Schizophr Res. 2009 Jan;107(1):47-54. doi: 10.1016/j.schres.2008.09.006. Epub 2008 Oct 18.
Social cognitive deficits are promising treatment targets for new interventions to improve functional outcome in schizophrenia. A few preliminary studies of inpatients support the feasibility of improving social cognition through psychosocial interventions. This clinical trial evaluated a new 12-session social cognitive skills training program designed to address four aspects of social cognition (affect perception, social perception, attributional style, Theory of Mind) in outpatients with psychosis, a population for whom such interventions will likely be very useful. Thirty-one clinically stabilized outpatients were randomly assigned to a social cognition skills training intervention or a time-matched control condition (illness self-management and relapse prevention skills training), and completed pre- and post-treatment assessments of social cognition, neurocognition, and symptoms. The social cognition group demonstrated a large, significant improvement in facial affect perception, which was not present in the control group. This improvement was independent of changes in basic neurocognitive functioning or symptoms. Results support the efficacy of a social cognitive intervention for community-dwelling outpatients and encourage further development of this treatment approach to achieve broader improvements in social cognition and generalization of treatment gains.
社会认知缺陷是改善精神分裂症功能结局的新干预措施的有前景的治疗靶点。对住院患者的一些初步研究支持了通过心理社会干预改善社会认知的可行性。这项临床试验评估了一个新的为期12节的社会认知技能培训项目,该项目旨在解决精神病门诊患者社会认知的四个方面(情感感知、社会感知、归因风格、心理理论),这类干预措施对这一人群可能非常有用。31名临床病情稳定的门诊患者被随机分配到社会认知技能培训干预组或时间匹配的对照条件组(疾病自我管理和复发预防技能培训),并完成了治疗前和治疗后的社会认知、神经认知及症状评估。社会认知组在面部情感感知方面有显著的大幅改善,而对照组则没有。这一改善与基本神经认知功能或症状的变化无关。结果支持了针对社区门诊患者的社会认知干预的有效性,并鼓励进一步发展这种治疗方法,以在社会认知方面取得更广泛的改善并使治疗效果得到推广。