Krambeck Amy E, Leroy Andrew J, Patterson David E, Gettman Matthew T
Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, Minnesota 55906, USA.
J Urol. 2008 Dec;180(6):2545-9. doi: 10.1016/j.juro.2008.08.032. Epub 2008 Oct 19.
Treatment for symptomatic calculi in the transplanted kidney can be problematic. Percutaneous nephrolithotomy has routinely been used but concerns exist about potential injury to adjacent organs using a percutaneous access technique. We report our experience with percutaneous nephrolithotomy in the transplant kidney.
A retrospective chart review from 1988 to the present was performed of all cases of a renal transplant and subsequent renal calculi treated with percutaneous nephrolithotomy.
We identified 13 patients with a renal transplant who underwent percutaneous nephrolithotomy. Presenting symptoms included renal failure in 46.1% of cases, hematuria in 23.1%, urinary tract infection/pyelonephritis in 23.1%, pain in 15.4%, fever in 7.7% and hydronephrosis in 7.7%. Average calculus size was 1.36 cm (range 0.2 to partial staghorn). A single access tract was used in 12 cases and 2 access tracts were used in 1. Ultrasonic lithotripsy was performed in 10 cases, basket extraction was performed in 3 and the 2 techniques were performed in 1. No intraoperative complications occurred. Nephrostogram 24 hours after the procedure demonstrated no residual fragments in 10 patients (76.9%). Repeat endoscopy was required in 3 patients to achieve subsequent stone-free status. Postoperative complications developed in 3 patients, including sepsis, gastrointestinal bleeding and herpes esophagitis, respectively. Mean followup was 5.3 years (range 0.6 to 9). The single stone recurrence was treated with shock wave lithotripsy. Mean creatinine was stable at 2.0 mg/dl (range 0.9 to 3.9) preoperatively to 1.7 mg/dl (range 0.9 to 2.6) at the last visit (p = 0.311).
Percutaneous nephrolithotomy is safe and effective in the transplanted kidney. Minimal postoperative complications were noted and stone-free status was achieved in all cases. At long-term followup there were few stone recurrences with stable graft function after the procedure.
移植肾有症状结石的治疗可能存在问题。经皮肾镜取石术一直被常规使用,但对于使用经皮穿刺技术可能对邻近器官造成的损伤存在担忧。我们报告我们在移植肾经皮肾镜取石术方面的经验。
对1988年至今所有接受肾移植及随后经皮肾镜取石术治疗肾结石的病例进行回顾性图表分析。
我们确定了13例接受肾移植并接受经皮肾镜取石术的患者。出现的症状包括46.1%的病例为肾衰竭,23.1%为血尿,23.1%为尿路感染/肾盂肾炎,15.4%为疼痛,7.7%为发热,7.7%为肾积水。结石平均大小为1.36厘米(范围0.2至部分鹿角形结石)。12例使用单一穿刺通道,1例使用2个穿刺通道。10例进行了超声碎石术,3例进行了套石篮取石,1例同时使用了这两种技术。术中无并发症发生。术后24小时肾造影片显示10例患者(76.9%)无残留结石碎片。3例患者需要再次进行内镜检查以达到无结石状态。3例患者出现术后并发症,分别为脓毒症、胃肠道出血和疱疹性食管炎。平均随访时间为5.3年(范围0.6至9年)。单发结石复发采用冲击波碎石术治疗。术前平均肌酐稳定在2.0毫克/分升(范围0.9至3.9),最后一次随访时为1.7毫克/分升(范围0.9至2.6)(p = 0.311)。
经皮肾镜取石术在移植肾中是安全有效的。术后并发症极少,所有病例均达到无结石状态。长期随访显示术后结石复发很少,移植肾功能稳定。