在小鼠中，吗啡 -6- 葡萄糖醛酸酯比吗啡更有效地诱导回肠环行肌收缩。

Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice.

作者信息

Iwata Hiroki, Tsuchiya Shizuko, Ueno Koichi, Nakamura Tomonori, Yano Shingo

机构信息

Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana, Chiba, Japan.

出版信息

Eur J Pharmacol. 2008 Dec 14;600(1-3):130-2. doi: 10.1016/j.ejphar.2008.10.009. Epub 2008 Oct 10.

DOI:10.1016/j.ejphar.2008.10.009

PMID:18930729

Abstract

It has been reported that morphine-6-glucuronide inhibits small intestinal transit in mice more potently than morphine. In this study, we investigated the effects of morphine, morphine-6-glucuronide and morphine-3-glucuronide on the contractile response of the circular muscle isolated from mouse ileum. Morphine and morphine-6-glucuronide induced tonic contraction dose-dependently, and the contractile force of morphine-6-glucuronide was greater than that of morphine. Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice.

摘要

据报道，吗啡 - 6 - 葡萄糖醛酸苷比吗啡更有效地抑制小鼠小肠蠕动。在本研究中，我们研究了吗啡、吗啡 - 6 - 葡萄糖醛酸苷和吗啡 - 3 - 葡萄糖醛酸苷对从小鼠回肠分离的环形肌收缩反应的影响。吗啡和吗啡 - 6 - 葡萄糖醛酸苷剂量依赖性地诱导强直性收缩，且吗啡 - 6 - 葡萄糖醛酸苷的收缩力大于吗啡。吗啡 - 3 - 葡萄糖醛酸苷在高剂量时诱导轻微收缩。这些结果表明，吗啡 - 6 - 葡萄糖醛酸苷诱导的强烈收缩促成了对小鼠小肠蠕动的抑制。