Lee Kang Soo, Chung Ji Hyung, Lee Kyung Hye, Shin Min-Jeong, Oh Byoung Hoon, Hong Chang Hyung
Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea.
Immunol Lett. 2008 Dec 22;121(2):105-9. doi: 10.1016/j.imlet.2008.09.004. Epub 2008 Oct 18.
Inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. Sixty-nine subjects were consecutively recruited from October 2005 to February 2007. Fifteen individuals were excluded from the study and we ultimately enrolled 19 not cognitively impaired subjects, 25 mild cognitive impairment patients, and 10 Alzheimer's disease patients. To examine the inflammatory markers of mild cognitive impairment and Alzheimer's disease, we measured the plasma concentrations of 23 cytokines using a bioplex assay. The results showed that the macrophage migration inhibitory factor was higher in mild cognitive impairment and in Alzheimer's disease patients compared with the not cognitively impaired group; the results also showed that monokine induced by gamma interferon was higher in Alzheimer's disease patients than in not cognitively impaired subjects, as well as those of the mild cognitive impairment group [corrected].
中枢神经系统内的炎症机制通过细胞因子介导的神经元与神经胶质细胞之间的相互作用导致认知障碍。2005年10月至2007年2月连续招募了69名受试者。15名个体被排除在研究之外，最终我们纳入了19名无认知障碍的受试者、25名轻度认知障碍患者和10名阿尔茨海默病患者。为了检测轻度认知障碍和阿尔茨海默病的炎症标志物，我们使用生物芯片分析法测量了23种细胞因子的血浆浓度。结果显示，与无认知障碍组相比，轻度认知障碍患者和阿尔茨海默病患者的巨噬细胞迁移抑制因子水平更高；结果还显示，γ干扰素诱导的单核细胞因子在阿尔茨海默病患者中高于无认知障碍受试者以及轻度认知障碍组[校正后]。
