Johansson Stefan, Buchmayer Susanne, Harlid Sophia, Iliadou Anastasia, Sjöholm Malin, Grillner Lena, Norman Mikael, Sparén Pär, Dillner Joakim, Cnattingius Sven
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.
Reprod Toxicol. 2008 Nov-Dec;26(3-4):298-302. doi: 10.1016/j.reprotox.2008.09.012. Epub 2008 Oct 9.
We investigated whether infections with Parvovirus B19 and Herpes viruses in early pregnancy increase risks of second trimester miscarriage or delivery before 32 gestational weeks. Blood samples taken in early pregnancy were analyzed for Parvovirus B19 or Herpes viruses. Viremia was found in blood samples of 11 (4.7%) women with second trimester miscarriage and 10 (3.7%) women with very preterm birth, compared to 5 (1.7%) women who delivered at term, corresponding to adjusted odds ratios [95% CI] of 3.32 [0.93, 11.8] and 2.21 [0.71, 6.84], respectively. In stratified analyses, Parvovirus B19 viremia was associated with adjusted odds ratios of 3.76 [0.77, 18.3] for second trimester miscarriage and 2.66 [0.64, 11.1] for very preterm birth. Corresponding odds ratios for Human Herpes virus 6 viremia was 2.52 [0.33, 19.5] and 1.08 [0.14, 8.08], respectively. In conclusion, this study lends some support to the hypothesis that women with viremia in early pregnancy may face an increased risk of second trimester miscarriage or very preterm birth. Studies with larger sample sizes are needed.
我们调查了妊娠早期感染细小病毒B19和疱疹病毒是否会增加孕中期流产或妊娠32周前分娩的风险。对妊娠早期采集的血样进行细小病毒B19或疱疹病毒分析。在11名（4.7%）孕中期流产的女性和10名（3.7%）极早产的女性血样中发现病毒血症，而足月分娩的女性中有5名（1.7%）发现病毒血症，相应的调整后比值比[95%置信区间]分别为3.32[0.93，11.8]和2.21[0.71，6.84]。在分层分析中，细小病毒B19病毒血症与孕中期流产的调整后比值比为3.76[0.77，18.3]，与极早产的调整后比值比为2.66[0.64，11.1]。人疱疹病毒6病毒血症的相应比值比分别为2.52[0.33，19.5]和1.08[0.14，8.08]。总之，本研究为妊娠早期病毒血症的女性可能面临孕中期流产或极早产风险增加这一假设提供了一些支持。需要进行更大样本量的研究。
