青藤碱透皮贴剂的研制与评价。

Development and evaluation of the Sinomenine transdermal patch.

作者信息

Wang Jianping, Ruan Jinlan, Zhang Changgong, Ye Yujie, Cai Yaling, Wu Yunxia

机构信息

School of Pharmacy, Tongji Medical Center, Huazhong University of Science and Technology, Wuhan-430030, P.R. China.

出版信息

Pak J Pharm Sci. 2008 Oct;21(4):407-10.

PMID:18930863

Abstract

Sinomenine transdermal patch was prepared and its properties were studied. The patches were produced by salivation method. The releasing rate in vitro of the patch was determined by HPLC. Peel test was used to evaluate the adhesion. Acute skin irritation test was performed in comparison with formalin (0.8%) by using mouse model. The Sinomenine TDDS Patch was prepared. The releasing rate in vitro followed the Higuchi equation (r>0.99), the releasing amount was beyond 90% in 24h. The peel adhesion to steel (N/25 mm) is 10 or above. The skin irritation tests showed negligible erythema and edema. The Sinomenine transdermal patch was prepared successfully and it may be beneficial for topical use.

摘要

制备了青藤碱透皮贴剂并对其性质进行了研究。贴剂采用流涎法制备。通过高效液相色谱法测定贴剂的体外释放速率。采用剥离试验评估黏附性。使用小鼠模型与福尔马林（0.8%）进行比较，进行急性皮肤刺激性试验。制备了青藤碱透皮给药系统贴剂。体外释放速率符合 Higuchi 方程（r>0.99），24 小时内释放量超过 90%。对钢的剥离黏附力（N/25 mm）为 10 或以上。皮肤刺激性试验显示红斑和水肿可忽略不计。成功制备了青藤碱透皮贴剂，其可能有利于局部应用。