P Subish, P Mishra, Pr Shankar
Department of Pharmacology, Manipal College of Medical Sciences / Manipal Teaching Hospital, Phulbari-11, Pokhara, Nepal.
Pak J Pharm Sci. 2008 Oct;21(4):465-7.
Present study analyzed the pattern, causality, severity and preventability of the systemic adverse drug reactions reported to the regional pharmacovigilance center during the period 14th September 2004 till 13th September 2005. Altogether the centre received 22 systemic adverse drug reactions [males 12 (54.55%), females 10 (45.45%)]. Among the total adverse drug reaction 5 (22.73%) were reported by the Department of Orthopedics. Of the 22 drugs responsible for the suspected adverse drug reaction, majority belongs to the class of opioid analgesics [n=7, (31.82%)], followed by non steroidal anti-inflammatory drugs [n=5, (22.73%)]. Tramadol was the individual drug responsible for 6 (27.27%) adverse drug reactions and vomiting was the most common adverse drug reactions [n=6, (27.27%)]. The causality assessment revealed 7 (31.82%) of the adverse drug reaction to have a probable relationship with the suspected drugs.
本研究分析了2004年9月14日至2005年9月13日期间向地区药物警戒中心报告的全身性药物不良反应的模式、因果关系、严重程度和可预防性。该中心共收到22例全身性药物不良反应报告[男性12例（54.55%），女性10例（45.45%）]。在所有药物不良反应中，有5例（22.73%）是由骨科报告的。在导致疑似药物不良反应的22种药物中，大多数属于阿片类镇痛药[7种（31.82%）]，其次是非甾体抗炎药[5种（22.73%）]。曲马多是导致6例（27.27%）药物不良反应的单一药物，呕吐是最常见的药物不良反应[6例（27.27%）]。因果关系评估显示，7例（31.82%）药物不良反应与疑似药物可能有关。
