Kiluk A, Namiot D B, Namiot Z, Leszczyńska K, Kurylonek A J, Kemona A
Department of Medicine and Gastroenterology, District Hospital, and Department of Prosthetic Dentistry, Medical University of Białystok, Białystok, Poland.
Adv Med Sci. 2008;53(2):305-9. doi: 10.2478/v10039-008-0041-9.
Erosive esophagitis frequently develops after successful Helicobacter pylori eradication. Since salivary secretion of epidermal growth factor (EGF) plays a crucial role in the pathogenesis of gastroesophageal reflux disease, the current study objective was to find out whether erosive esophagitis development after Helicobacter pylori eradication is associated with the secretion of EGF in saliva.
A total of 115 H. pylori infected patients (positive results of CLO-test, histology and serology) with a duodenal ulcer were recruited for the study. Gastroscopic examinations and saliva collections were performed twice, prior to H. pylori eradication and one year after its cessation. The salivary EGF was determined using a radioimmunological method.
Salivary EGF secretion was lower in H. pylori infected subjects with erosive esophagitis than without (0.82+/-0.66 vs 1.70+/-3.49 ng/min, p=0.021). However, a year after successful H. pylori eradication, salivary EGF did not differ between the groups (2.17+/-2.06 vs 1.79+/-2.06 ng/min); the lack of difference was due to high peptide secretion in patients who developed erosive esophagitis after eradication.
Erosive esophagitis development following H. pylori eradication is not the result of decreased salivary EGF secretion.
幽门螺杆菌成功根除后，糜烂性食管炎常随之发生。由于表皮生长因子（EGF）的唾液分泌在胃食管反流病的发病机制中起关键作用，本研究的目的是探讨幽门螺杆菌根除后糜烂性食管炎的发生是否与唾液中EGF的分泌有关。
本研究共纳入115例感染幽门螺杆菌（CLO试验、组织学和血清学检查结果均为阳性）且患有十二指肠溃疡的患者。在幽门螺杆菌根除前和根除后一年分别进行两次胃镜检查和唾液采集。采用放射免疫法测定唾液中的EGF。
患有糜烂性食管炎的幽门螺杆菌感染受试者的唾液EGF分泌低于未患糜烂性食管炎的受试者（0.82±0.66对1.70±3.49 ng/min，p = 0.021）。然而，在幽门螺杆菌成功根除一年后，两组之间的唾液EGF无差异（2.17±2.06对1.79±2.06 ng/min）；缺乏差异的原因是根除后发生糜烂性食管炎的患者肽分泌量高。
幽门螺杆菌根除后糜烂性食管炎的发生并非唾液EGF分泌减少所致。
