Leach J K, Strickland R D, Millis D L, Stremsterfer C E, Skipper B J
Am J Hosp Pharm. 1977 Jul;34(7):709-12.
The effect of long-term storage in polyvinyl chloride bags on the biological activity and the chemical stability of isoproterenol was studied. A freshly prepared solution of isoproterenol, isoproterenol solution stored for six months and isoproterenol stored for 30 months were infused into the coronary circulation of 14 isolated rabbit hearts; heart rates were determined. Spectrophotometric studies to determine stability at various pH levels were also done. Aging of the solutions at pH 4 and at a concentration of 4 microgram/ml caused no significant impairment of their potency. Solutions above pH 6 were unstable.
研究了异丙肾上腺素在聚氯乙烯袋中长期储存对其生物活性和化学稳定性的影响。将新配制的异丙肾上腺素溶液、储存6个月的异丙肾上腺素溶液和储存30个月的异丙肾上腺素注入14个离体兔心脏的冠状动脉循环中，测定心率。还进行了分光光度研究以确定在不同pH水平下的稳定性。在pH 4、浓度为4微克/毫升的条件下，溶液老化对其效力没有显著损害。pH 6以上的溶液不稳定。
