铁调素对铁转运的调节作用。
Hepcidin regulation of iron transport.
作者信息
Collins James F, Wessling-Resnick Marianne, Knutson Mitchell D
机构信息
Department of Exercise and Nutrition Sciences, University at Buffalo, the State University of New York, Buffalo, NY 14214, USA.
出版信息
J Nutr. 2008 Nov;138(11):2284-8. doi: 10.3945/jn.108.096347.
Abstract
The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.
摘要
铁调素作为铁稳态关键调节因子的发现推动了我们对该领域的现有认知。肝脏来源的铁调素肽会响应铁和炎症而分泌，并与铁输出蛋白铁转运蛋白相互作用。本综述总结了研讨会上讨论的最新进展。特别关注的是铁调素与铁转运蛋白之间的分子相互作用、铁和炎症对铁调素表达的调节，以及在人群中测量血清铁调素的新兴方法。
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