Zou Pengjian, He Qiuming, Xia Huimin, Zhong Wei
Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
PeerJ. 2024 Dec 19;12:e18708. doi: 10.7717/peerj.18708. eCollection 2024.
Ferroptosis is a novel form of programmed cell death characterized by iron accumulation, lipid peroxidation, and a decline in antioxidant capacity, all of which are regulated by gene expression. The onset of numerous diseases is closely associated with ferroptosis. Common diseases affect a large population, reduce the quality of life, and impose an increased burden on the healthcare system. The role of ferroptosis in common diseases, its therapeutic potential, and even its translation into clinical drug treatments are currently significant research topics worldwide. This study preliminarily explores the theoretical basis of ferroptosis, its mechanism and treatment prospect in common diseases including ischaemia-reperfusion injury, inflammatory bowel diseases, liver fibrosis, acute kidney injury, diabetic kidney disease, stroke, Alzheimer's disease, cardiovascular disease, immune and cancer. This review provides a theoretical foundation for the further study and development of ferroptosis, as well as for the prevention and treatment of common diseases.
铁死亡是一种新型的程序性细胞死亡形式，其特征为铁蓄积、脂质过氧化和抗氧化能力下降，所有这些均受基因表达调控。众多疾病的发生都与铁死亡密切相关。常见疾病影响大量人群，降低生活质量，并给医疗系统带来日益加重的负担。铁死亡在常见疾病中的作用、其治疗潜力，甚至其转化为临床药物治疗，目前都是全球重要的研究课题。本研究初步探讨了铁死亡的理论基础、其在包括缺血再灌注损伤、炎症性肠病、肝纤维化、急性肾损伤、糖尿病肾病、中风、阿尔茨海默病、心血管疾病、免疫性疾病和癌症等常见疾病中的机制及治疗前景。本综述为铁死亡的进一步研究和开发以及常见疾病的预防和治疗提供了理论基础。
