Umehara F, Nomoto M, Usuki F, Matsumoto W, Osame M
Department of Neurology, Kagoshima Prefectural Ohshima Hospital.
Rinsho Shinkeigaku. 1991 Mar;31(3):306-9.
A pair of monozygotic twins concordant for juvenile Parkinsonism are described. These twin sisters have lived together until 18 years old. Twin A noted tremor in the right hand and right-sided stiffness and slowness at the age 20. Initially, a marked improvement was shown with L-dopa treatment. However, one year after the beginning of treatment, dopa-induced dyskinesia appeared. Twin B noted tremor and right-sided stiffness and basal ganglia calcification in both patients. These twin patients suggest that genetic factors may play an important role in the cause of juvenile Parkinsonism.
本文描述了一对患青少年帕金森病的同卵双胞胎。这对双胞胎姐妹一直共同生活到18岁。双胞胎A在20岁时出现右手震颤、右侧肢体僵硬和运动迟缓。最初，左旋多巴治疗显示出明显改善。然而，治疗开始一年后，出现了多巴诱导的运动障碍。双胞胎B在两名患者中均发现震颤、右侧肢体僵硬和基底节钙化。这对双胞胎患者提示遗传因素可能在青少年帕金森病的病因中起重要作用。
