Patel S R, Blackwell T, Redline S, Ancoli-Israel S, Cauley J A, Hillier T A, Lewis C E, Orwoll E S, Stefanick M L, Taylor B C, Yaffe K, Stone K L
Division of Pulmonary, Critical Care, and Sleep Medicine and Center for Clinical Investigation, University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, OH 44106, USA.
Int J Obes (Lond). 2008 Dec;32(12):1825-34. doi: 10.1038/ijo.2008.198. Epub 2008 Oct 21.
Reduced sleep has been reported to predict obesity in children and young adults. However, studies based on self-report have been unable to identify an association in older populations. In this study, the cross-sectional associations between sleep duration measured objectively and measures of weight and body composition were assessed in two cohorts of older adults.
Wrist actigraphy was performed for a mean (s.d.) of 5.2 (0.9) nights in 3055 men (age: 67-96 years) participating in the Osteoporotic Fractures in Men Study (MrOS) and 4.1 (0.8) nights in 3052 women (age: 70-99 years) participating in the Study of Osteoporotic Fractures (SOF). A subgroup of 2862 men and 455 women also underwent polysomnography to measure sleep apnea severity.
Compared to those sleeping an average of 7-8 h per night, and after adjusting for multiple risk factors and medical conditions, a sleep duration of less than 5 h was associated with a body mass index (BMI) that was on average 2.5 kg/m(2) (95% confidence interval (CI): 2.0-2.9) greater in men and 1.8 kg/m(2) (95% CI: 1.1-2.4) greater in women. The odds of obesity (BMI >or= 30 kg/m(2)) was 3.7-fold greater (95% CI: 2.7-5.0) in men and 2.3-fold greater in women (95% CI: 1.6-3.1) who slept less than 5 h. Short sleep was also associated with central body fat distribution and increased percent body fat. These associations persisted after adjusting for sleep apnea, insomnia and daytime sleepiness.
In older men and women, actigraphy-ascertained reduced sleep durations are strongly associated with greater adiposity.
据报道，睡眠减少可预测儿童和年轻人肥胖。然而，基于自我报告的研究未能在老年人群中发现这种关联。在本研究中，在两组老年人群中评估了客观测量的睡眠时间与体重和身体成分测量值之间的横断面关联。
对参与男性骨质疏松性骨折研究（MrOS）的3055名男性（年龄：67 - 96岁）平均（标准差）进行了5.2（0.9）晚的腕部活动监测，对参与骨质疏松性骨折研究（SOF）的3052名女性（年龄：70 - 99岁）平均进行了4.1（0.8）晚的腕部活动监测。2862名男性和455名女性的亚组还进行了多导睡眠监测以测量睡眠呼吸暂停严重程度。
与每晚平均睡眠7 - 8小时的人相比，在调整了多种风险因素和健康状况后，睡眠时间少于5小时的男性体重指数（BMI）平均高2.5 kg/m²（95%置信区间（CI）：2.0 - 2.9），女性高1.8 kg/m²（95% CI：1.1 - 2.4）。睡眠时间少于5小时的男性肥胖（BMI≥30 kg/m²）几率高3.7倍（95% CI：2.7 - 5.0），女性高2.3倍（95% CI：1.6 - 3.1）。短睡眠还与中心性体脂分布和体脂百分比增加有关。在调整睡眠呼吸暂停、失眠和日间嗜睡后，这些关联依然存在。
在老年男性和女性中，通过活动监测确定的睡眠时间减少与更高的肥胖程度密切相关。
