Alekseev S I, Szabo I, Ziskin M C
Center for Biomedical Physics, Temple University Medical School, Philadelphia, PA 19140, USA.
Skin Res Technol. 2008 Nov;14(4):390-6. doi: 10.1111/j.1600-0846.2008.00319.x.
BACKGROUND/AIMS: A new non-invasive method for determining the free water content in human skin has been developed. The method analyzes the reflection of millimeter (mm) wavelength electromagnetic waves. The amount of reflection of mm waves depends on an electrical property (namely, the permittivity) of the skin, and this depends upon the free water content of the various skin layers. The aim of the present study was to use the mm wave reflectometry method for determination of free water content in healthy skin treated with different hydrating substances.
Skin lotion, pure water, glycerol, and petroleum jelly (an occlusive substance) were used for hydration of skin. The amount of free water was calculated using the permittivity values of skin layers found from fitting a three layer skin model to measured reflection data. The skin model consisted of (1) the stratum corneum (SC), (2) the viable epidermis plus the dermis, and (3) fat layers.
Mm wave reflection was significantly affected by the water content of the thick SC of the palm but not by the very thin SC of the forearm. Treatment of the forearm and palm skin with different hydrating substances produced notable changes of the free water content in the SC, but not in the viable epidermis or dermis. The greatest hydration was produced by pure water and skin lotion, and the lowest by petroleum jelly. However, petroleum jelly produced prolonged retention of water in the SC following its hydration by other moisturizers. The content of free water was found to return to its baseline value after removal of moisturizers in as short a time as 8.3 min.
The study shows that mm wave reflectometry can be used as a sensitive technique for the non-invasive determination of water content in living skin.
背景/目的:已开发出一种用于测定人体皮肤中自由水含量的新的非侵入性方法。该方法分析毫米波(mm)波长电磁波的反射情况。毫米波的反射量取决于皮肤的一种电特性(即介电常数),而这又取决于各皮肤层的自由水含量。本研究的目的是使用毫米波反射测量法来测定用不同保湿物质处理的健康皮肤中的自由水含量。
使用护肤液、纯水、甘油和凡士林(一种封闭性物质)对皮肤进行保湿处理。通过将三层皮肤模型拟合到测量的反射数据来找到皮肤层的介电常数,进而计算自由水的含量。该皮肤模型由(1)角质层(SC)、(2)有活力的表皮加真皮以及(3)脂肪层组成。
毫米波反射受到手掌较厚角质层含水量的显著影响,但不受前臂极薄角质层含水量的影响。用不同保湿物质处理前臂和手掌皮肤会使角质层中的自由水含量发生显著变化,但对有活力的表皮或真皮中的自由水含量没有影响。纯水和护肤液产生的保湿效果最佳,凡士林产生的保湿效果最差。然而,凡士林在被其他保湿剂保湿后,能使角质层中的水分长时间保留。发现去除保湿剂后,自由水含量在短至8.3分钟的时间内就会恢复到基线值。
该研究表明毫米波反射测量法可作为一种灵敏的技术,用于非侵入性测定活体皮肤中的水分含量。