Huang Ke, Tang Wei, Xu Zhao, Li Zhiqiang, He Zhangdong, Tang Ruqi, Che Ronglin, Xu Yifeng, Li Xingwang, Feng Guoyin, He Lin, Shi Yongyong
Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, China.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):33-6. doi: 10.1016/j.pnpbp.2008.09.027. Epub 2008 Oct 11.
Schizophrenia is a chronic psychiatric disorder with a strong genetic component. Several recent published studies have reported that the mRNA expression level of quaking homolog, KH domain RNA binding (QKI) is down regulated in individuals diagnosed with schizophrenia.
We were interested in the genetic variants around the promoter region of QKI and selected seven variants in this region, namely rs4263561, rs3904720, rs387504, rs3763197, rs7772756, rs7758706 and rs4709716. For the study we recruited 288 individuals diagnosed with schizophrenia and 288 control subjects. All the recruits were from Shanghai and were Han Chinese in origin.
No individual SNP nor any haplotype was found to be associated with schizophrenia.
These results suggest that the variants within the promoter region of QKI gene are unlikely to play a major role in susceptibility to schizophrenia in the Chinese population.
精神分裂症是一种具有强大遗传成分的慢性精神疾病。最近发表的几项研究报告称，在被诊断为精神分裂症的个体中，震颤同源物、KH结构域RNA结合蛋白（QKI）的mRNA表达水平下调。
我们对QKI启动子区域周围的遗传变异感兴趣，并在该区域选择了7个变异，即rs4263561、rs3904720、rs387504、rs3763197、rs7772756、rs7758706和rs4709716。在这项研究中，我们招募了288名被诊断为精神分裂症的个体和288名对照受试者。所有受试者均来自上海，为汉族。
未发现单个单核苷酸多态性（SNP）或任何单倍型与精神分裂症相关。
这些结果表明，QKI基因启动子区域内的变异不太可能在中国人群对精神分裂症的易感性中起主要作用。
