Chávez Edmundo, García Noemí, Pavón Natalia
Departamento de Bioquímica, Instituto Nacional de Cardiología "Ignacio Chávez", INCICH, Juan Badiano Núm. 1, Col. Sección XVI, Tlalpan 14080, México, DF.
Arch Cardiol Mex. 2007 Oct-Dec;77 Suppl 4:S4-77-81.
The results presented in this study indicate that the immunosuppressor cyclosporine A acts as a cardioprotective drug.
This effect was analyzed during development of reperfusion-induced arrhythmias after 5 min period of coronary ligation in hearts of rats under anesthesia.
The results indicate that cyclosporine inhibits Ca(2+)-induced mitochondrial damage; furthermore, when given before coronary occlusion, at a dose of 20 mg/kg, effectively protects against the high incidence of arrhythmias and the fall in blood pressure induced by reperfusion. In addition, it inhibits the delivery of lactic dehydrogenase and creatine kinase enzymes to the plasma.
We propose that the protective effect could be related with its well documented action to restrain Ca(2+)-induced damage of mitochondrial functions.
本研究呈现的结果表明，免疫抑制剂环孢素A具有心脏保护作用。
在麻醉大鼠心脏冠状动脉结扎5分钟后再灌注诱导心律失常的过程中分析这种作用。
结果表明，环孢素抑制钙诱导的线粒体损伤；此外，在冠状动脉闭塞前以20mg/kg的剂量给药时，可有效预防再灌注诱导的心律失常高发以及血压下降。此外，它还能抑制乳酸脱氢酶和肌酸激酶向血浆的释放。
我们认为这种保护作用可能与其抑制钙诱导的线粒体功能损伤这一已被充分证明的作用有关。
