Matsubara Akihiro, Shimizu Yuya, Karamatsu Katsuo, Yasutomi Yasuhiro
Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate Research Center, National Institute of Biomedical Innovation.
Nihon Rinsho. 2008 Oct;66(10):1873-8.
In the increasing crisis of pandemic of infectious diseases all over the world in recent years, it is the most necessary to develop readily available vaccines even in developing countries. Since many pathogens establish their initial infections through the mucosal surface in our bodies, the induction of mucosal immune responses by vaccines are thought to be important for the prevention of infectious diseases through mucosal site. Oral administration of vaccines has abilities to elicit mucosal immune responses at mucosal tissues with various advantages such as easy skill for administration, less stressful for vaccine recipients and safer than systemic injection. Here, we show our novel strategies for inducing mucosal immune responses by oral vaccine administration.
在近年来全球日益严重的传染病大流行危机中，即使在发展中国家，开发易于获得的疫苗也是最为必要的。由于许多病原体通过我们身体的粘膜表面建立初始感染，因此疫苗诱导粘膜免疫反应被认为对于通过粘膜部位预防传染病很重要。口服疫苗能够在粘膜组织引发粘膜免疫反应，具有诸如给药技术简便、对疫苗接种者压力较小以及比全身注射更安全等各种优点。在此，我们展示了通过口服疫苗给药诱导粘膜免疫反应的新策略。
